Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors.
نویسندگان
چکیده
The melanotropin peptides alpha-MSH, gamma-MSH, and beta-MSH are believed to be the natural ligands for the four melanocortin receptors, MC1R, MC3R, MC4R, and MC5R. However, these peptides generally have low selectivity for these receptors. We report on some approaches to the development of selective agonists and antagonists peptide ligands for these receptors.
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 994 شماره
صفحات -
تاریخ انتشار 2003